Piezo1 agonist 1-d2 is a selective agonist for the Piezo1 ion channel, exhibiting an EC50 of 2.21 μM. This compound activates Ca2+-dependent ERK signaling pathways, thereby facilitating the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Additionally, Piezo1 agonist 1-d2 has demonstrated efficacy in ameliorating disuse osteoporosis in hindlimb-unloading rat models, making it a valuable tool for research in bone health and regenerative medicine.
Piezo1 agonist 1-d2 is a selective agonist for the Piezo1 ion channel, exhibiting an EC50 of 2.21 μM. This compound activates Ca2+-dependent ERK signaling pathways, thereby facilitating the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Additionally, Piezo1 agonist 1-d2 has demonstrated efficacy in ameliorating disuse osteoporosis in hindlimb-unloading rat models, making it a valuable tool for research in bone health and regenerative medicine.
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