Fig. 1 · Structure

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Pim1/AAK1-IN-1

LKB1/AAK1 dual inhibitor

Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
Huh-7 CC50 > 10 μM Cytotoxicity against human HuH7 cells infected with Ebolavirus Kikwit isolate after 48 hrs by Celltiter-glo reagent based luminescence assay [PMID: 31136173]
Huh-7 CC50 > 50 μM Cytotoxicity against human HuH7 cells infected with DENV2 New Guinea C by microplate alamar blue assay [PMID: 31136173]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 1093222-27-5
Applications

LKB1/AAK1 dual inhibitor

Formula C20H13N5O
Molecular Weight 339.35
Synonyms LKB1/AAK1 dual inhibitor
SMILES
N#CC1=CC=C(C2=CN=C3C(C(NC(C4=CC=CN=C4)=O)=CN3)=C2)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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