Fig. 1 · Structure
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PKUMDL-WQ-2101
PHGDH inhibitor
PKUMDL-WQ-2101 is a non-NAD+-competing allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH), with an IC50 of 34.8 μM. This compound demonstrates antitumor activity, making it a valuable tool for cancer research and therapeutic studies targeting metabolic pathways. Its specificity for PHGDH provides opportunities to investigate the enzyme's role in tumorigenesis and metabolic reprogramming in cancer cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 304481-72-9 |
| Applications | PHGDH inhibitor |
| Formula | C14H11N3O6 |
| Molecular Weight | 317.25 |
| SMILES | O=C(C1=CC=C(C=C1O)O)N/N=C/C2=CC([N+]([O-])=O)=CC=C2O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.