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$0.00 Biological Activity
Pladienolide B is the major analogue of a family of macrocyclic lactones isolated from Streptomyces platensis. Pladienolide B is a highly potent inhibitor of both hypoxia signals and cancer cell proliferation. Pladienolide B binds to SF3b complex blocking the spliceosome.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.63 mL | 93.16 mL | 186.32 mL |
| 0.5 mM | 3.73 mL | 18.63 mL | 37.26 mL |
| 1 mM | 1.86 mL | 9.32 mL | 18.63 mL |
| 5 mM | 0.37 mL | 1.86 mL | 3.73 mL |
*The above data is based on the productmolecular weight 536.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12699 |
|---|---|
| CAS No. | 445493-23-2 |
| Formula | C30H48O8 |
| M. Wt | 536.7 |
| Purity | >98% |
| SMILES | O[[email protected]]1CC(O[[email protected]](/C(C)=C/C=C/[[email protected]@H](C)C[[email protected]@H]2[[email protected]]([[email protected]](C)[[email protected]](CC)O)([H])O2)[[email protected]@H](C)/C=C/[[email protected]](OC(C)=O)[[email protected]](C)(O)CC1)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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