Pladienolide B

Catalog No.: A12699

Pladienolide B

Pladienolide B Chemical Structure

CAS NO. 445493-23-2

Pladienolide B is the major analogue of a family of macrocyclic lactones isolated from Streptomyces platensis. Pladienolide B is a highly potent inhibitor of both hypoxia signals and cancer cell proliferation. Pladienolide B binds to SF3b complex blocking the spliceosome.

Availability: In stock

Package Price Qty
0.5 mg
$500.00
1 mg
$800.00
2 mg
$1,500.00
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Biological Activity

Pladienolide B is the major analogue of a family of macrocyclic lactones isolated from Streptomyces platensis. Pladienolide B is a highly potent inhibitor of both hypoxia signals and cancer cell proliferation. Pladienolide B binds to SF3b complex blocking the spliceosome.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.63 mL 93.16 mL 186.32 mL
0.5 mM 3.73 mL 18.63 mL 37.26 mL
1 mM 1.86 mL 9.32 mL 18.63 mL
5 mM 0.37 mL 1.86 mL 3.73 mL

*The above data is based on the productmolecular weight 536.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12699
CAS No. 445493-23-2
Formula C30H48O8
M. Wt 536.7
Purity >98%
SMILES O[[email protected]]1CC(O[[email protected]](/C(C)=C/C=C/[[email protected]@H](C)C[[email protected]@H]2[[email protected]]([[email protected]](C)[[email protected]](CC)O)([H])O2)[[email protected]@H](C)/C=C/[[email protected]](OC(C)=O)[[email protected]](C)(O)CC1)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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