Fig. 1 · Structure
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PLpro/RBD-IN-1
PLpro/RBD Inhibitor
PLpro/RBD-IN-1 is a dual inhibitor targeting the SARS-CoV-2 papain-like protease (PLpro) and the spike protein receptor binding domain (RBD), exhibiting IC50 values of 7.197 μM and 8.673 μM, respectively. This compound offers significant potential for the development of antiviral agents against SARS-CoV-2 by hindering viral replication and entry into host cells. It serves as a valuable tool for researchers investigating therapeutic strategies for COVID-19.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1282451-83-5 |
| Applications | PLpro/RBD Inhibitor |
| Formula | C13H10N4O |
| Molecular Weight | 238.24 |
| SMILES | NC1=C(C=CC=C1)C2=NOC(C3=CC=NC=C3)=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.