Fig. 1 · Structure
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PMMB276
Tubb3 Inhibitor
PMMB276 is a potent inhibitor of β-tubulin isotype III (Tubb3) polymerization, leading to apoptosis in cancer cells. This compound is valuable in cancer research, particularly in studies focusing on tumor cell proliferation and the role of Tubb3 in oncogenesis. Its ability to disrupt microtubule dynamics offers insights into potential therapeutic strategies against Tubb3-overexpressing tumors.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2209036-28-0 |
| Applications | Tubb3 Inhibitor |
| Formula | C31H34O6S2 |
| Molecular Weight | 566.73 |
| SMILES | O=C(C1=C(C=CC(O)=C12)O)C=C([C@@H](C/C=C(C)/C)OC(CCCC[C@H]3SC(SCC3)C4=CC=CC=C4)=O)C2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.