Fig. 1 · Structure
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PMX 53 monoacetate
Cat. No.
A74497
CAS
852629-88-0
Endogenous Metabolite
PMX 53 monoacetate is a potent orally active antagonist of CD88 (C5aR), primarily inhibiting C5a-induced neutrophil myeloperoxidase release and chemotactic activity. It demonstrates an IC50 of 20 nM for myeloperoxidase release and 75 nM for chemotaxis, making it an effective tool for studying neutrophil responses. Additionally, PMX 53 monoacetate acts as an agonist of MrgX2, further broadening its potential applications in research involving inflammatory processes and pain signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 852629-88-0 |
| Applications | Endogenous Metabolite |
| Formula | C49H69N11O9 |
| Molecular Weight | 956.14 |
| Synonyms | 3D53 monoacetate |
| SMILES | CC(O)=O.O=C([C@H](NC([C@@]1([H])N(CCC1)C([C@H](CCCNC([C@@H](NC2=O)CCCNC(N)=N)=O)NC([C@@H](NC(C)=O)CC3=CC=CC=C3)=O)=O)=O)CC4CCCCC4)N[C@H]2CC5=CNC6=CC=CC=C56 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.