PMX 53 monoacetate is a potent orally active antagonist of CD88 (C5aR), primarily inhibiting C5a-induced neutrophil myeloperoxidase release and chemotactic activity. It demonstrates an IC50 of 20 nM for myeloperoxidase release and 75 nM for chemotaxis, making it an effective tool for studying neutrophil responses. Additionally, PMX 53 monoacetate acts as an agonist of MrgX2, further broadening its potential applications in research involving inflammatory processes and pain signaling pathways.
PMX 53 monoacetate is a potent orally active antagonist of CD88 (C5aR), primarily inhibiting C5a-induced neutrophil myeloperoxidase release and chemotactic activity. It demonstrates an IC50 of 20 nM for myeloperoxidase release and 75 nM for chemotaxis, making it an effective tool for studying neutrophil responses. Additionally, PMX 53 monoacetate acts as an agonist of MrgX2, further broadening its potential applications in research involving inflammatory processes and pain signaling pathways.
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