Fig. 1 · Structure
Documents & Downloads
Polθ-IN-4
Polθ Inhibitor
Polθ-IN-4 is a prodrug that serves as a potent inhibitor of DNA polymerase θ (Polθ), specifically targeting its ATP-dependent helicase domain. With kinetic constants (Kms) of 3.7 μM in both human and mouse models and 5.2 μM in rat recombinant alkaline phosphatases, this compound exhibits significant inhibition of Polθ activity. Polθ-IN-4 demonstrates notable anti-tumor efficacy in various animal models, positioning it as a valuable tool for research focused on breast and ovarian cancers.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3043810-73-4 |
| Applications | Polθ Inhibitor |
| Formula | C17H17ClN5O7PS |
| Molecular Weight | 501.84 |
| SMILES | ClC1=NC=C(OC)C(C2=C(C(/N=C3N(COP(O)(O)=O)N=C(OC)S/3)=O)C=NC(C)=C2)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.