Fig. 1 · Structure
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Polθ-IN-8
Polθ Inhibitor
Polθ-IN-8 is a selective inhibitor of DNA polymerase theta (Polθ), exhibiting an IC50 of less than 100 nM for Polθ ATPase activity. This compound is valuable for investigating the role of Polθ in cancer and other diseases associated with DNA repair processes. Its application in research provides insights into the molecular mechanisms of genomic instability and potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3056743-98-4 |
| Applications | Polθ Inhibitor |
| Formula | C22H22ClN7O3S |
| Molecular Weight | 499.97 |
| SMILES | O=C(C1=C(C2=CC(Cl)=NC=C2OC)C=C(C)N=C1)NC3=NC4=C(S3)N=C(NCC(C)(C)O)N=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.