Fig. 1 · Structure
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Ponatinib hydrochloride
Multi-targeted Kinase Inhibitor
Ponatinib hydrochloride is a potent multi-targeted kinase inhibitor that primarily acts on Abl, PDGFRα, VEGFR2, FGFR1, and Src, with respective IC50 values of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM. This compound is orally bioavailable and is widely utilized in cancer research, particularly in studies focused on chronic myeloid leukemia and solid tumors. Its ability to effectively inhibit multiple kinases makes it a valuable tool for elucidating kinase signaling pathways and evaluating potential therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1114544-31-8 |
| Applications | Multi-targeted Kinase Inhibitor |
| Formula | C29H28ClF3N6O |
| Molecular Weight | 569.02 |
| Synonyms | AP24534 hydrochloride |
| SMILES | O=C(C1=CC=C(C)C(C#CC2=CN=C3C=CC=NN23)=C1)NC4=CC=C(CN5CCN(CC5)C)C(C(F)(F)F)=C4.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.