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Populin

Aldose Reductase Inhibitor

Populin, also known as Populoside, is a phenolic glucoside that functions as an aldose reductase inhibitor, exhibiting an IC50 of 18.55 μM. It demonstrates significant antioxidant activity, with IC50 values of 6.76 µM and 1.69 mM in DPPH and ABTS radical-scavenging assays, respectively. By reducing D-sorbitol accumulation, Populin may be useful in investigating the pathophysiology of diabetic complications and exploring therapeutic interventions in diabetes-related research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	99-17-2
Applications	Aldose Reductase Inhibitor
Formula	C₂₀H₂₂O₈
Molecular Weight	390.38
Synonyms	Populoside; Salicin 6-benzoate; NSC 128308
SMILES	O=C(C1=CC=CC=C1)OC[C@H]([C@H]([C@@H]([C@H]2O)O)O)O[C@H]2OC3=C(C=CC=C3)CO

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.