Poststatin

Catalog No.: A77288
Prolyl Endopeptidase Inhibitor
Poststatin is a selective inhibitor of prolyl endopeptidase (PEP), a key enzyme involved in the degradation of bioactive peptides such as bradykinin. By inhibiting PEP, Poststatin enhances the levels of bradykinin, which may play a crucial role in modulating pain and inflammation. This reagent is valuable for research applications focused on pain pathways, inflammatory responses, and cardiovascular regulation.
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5mg
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50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPoststatin is a selective inhibitor of prolyl endopeptidase (PEP), a key enzyme involved in the degradation of bioactive peptides such as bradykinin. By inhibiting PEP, Poststatin enhances the levels of bradykinin, which may play a crucial role in modulating pain and inflammation. This reagent is valuable for research applications focused on pain pathways, inflammatory responses, and cardiovascular regulation.
Product Information
Catalog NumA77288
FormulaC26H47N5O7
Molecular Weight541.68
CAS Number135219-43-1
SequenceVal-Val-{Oaa}-{d-Leu}-Val
Sequence shorteningVV-{Oaa}-{d-Leu}-V
SMILESCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)C(=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(O)=O |@:15|
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