Pozanicline dihydrochloride is a selective agonist for nicotinic acetylcholine receptors (nAChRs), specifically targeting the α4β2 subtype with a binding affinity (Ki) of 17 nM at rat brain nAChR sites. It exhibits an affinity of 16.7 nM for [3H]cytisine binding sites, demonstrating its potential in modulating cholinergic signaling. This compound is instrumental in research focused on neurological disorders, cognition enhancement, and the exploration of nAChR-related pathways. Its oral bioavailability further supports its utility in in vivo studies.
Pozanicline dihydrochloride is a selective agonist for nicotinic acetylcholine receptors (nAChRs), specifically targeting the α4β2 subtype with a binding affinity (Ki) of 17 nM at rat brain nAChR sites. It exhibits an affinity of 16.7 nM for [3H]cytisine binding sites, demonstrating its potential in modulating cholinergic signaling. This compound is instrumental in research focused on neurological disorders, cognition enhancement, and the exploration of nAChR-related pathways. Its oral bioavailability further supports its utility in in vivo studies.
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