Pozanicline

Catalog No.: A21318

Pozanicline

Pozanicline Chemical Structure

CAS NO. 161417-03-4

Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at ??4??2* nAChRs (Ki=16 nM) and shows high selectivity for ??6??2* and ??4??5??2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM.

Availability: In stock

Package Price Qty
1 mg

Regular Price: $320.00

Special Price $256.00

5 mg

Regular Price: $960.00

Special Price $768.00

10 mg

Regular Price: $1,600.00

Special Price $1,280.00

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Biological Activity

Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at ??4??2* nAChRs (Ki=16 nM) and shows high selectivity for ??6??2* and ??4??5??2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 52.01 mL 260.06 mL 520.13 mL
0.5 mM 10.4 mL 52.01 mL 104.03 mL
1 mM 5.2 mL 26.01 mL 52.01 mL
5 mM 1.04 mL 5.2 mL 10.4 mL

*The above data is based on the productmolecular weight 192.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21318
CAS No. 161417-03-4
Formula C11H16N2O
M. Wt 192.26
Purity >98%
Synonyms ABT-089
SMILES CC1=C(OC[[email protected]]2NCCC2)C=CC=N1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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