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Biological Activity
Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at ??4??2* nAChRs (Ki=16 nM) and shows high selectivity for ??6??2* and ??4??5??2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 52.01 mL | 260.06 mL | 520.13 mL |
| 0.5 mM | 10.4 mL | 52.01 mL | 104.03 mL |
| 1 mM | 5.2 mL | 26.01 mL | 52.01 mL |
| 5 mM | 1.04 mL | 5.2 mL | 10.4 mL |
*The above data is based on the productmolecular weight 192.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21318 |
|---|---|
| CAS No. | 161417-03-4 |
| Formula | C11H16N2O |
| M. Wt | 192.26 |
| Purity | >98% |
| Synonyms | ABT-089 |
| SMILES | CC1=C(OC[[email protected]]2NCCC2)C=CC=N1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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