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Pozelimab

Pozelimab (REGN3918) is a fully humanized IgG4 monoclonal antibody specifically developed to target and bind with high affinity to complement component 5 (C5) and its variants. This antibody effectively inhibits the cleavage of C5, thereby blocking complement-mediated hemolysis. It is an essential tool for investigating the pathophysiology of complement-mediated disorders and is suitable for use in various research settings focused on these diseases.

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Product Details

Manufacturer Adooq Bioscience
Actions Antagonist
CAS Number 2096328-94-6
Molecular Weight 144780
Synonyms REGN3918

Storage

Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Customer Questions
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
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