PRMT5-IN-41 is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5), demonstrating potent enzymatic inhibition with oral bioavailability. In addition to its primary mechanism, PRMT5-IN-41 exhibits off-target inhibition of the hERG ion channel, with an IC50 value of 1.36 µM. This compound is valuable for research applications investigating the role of PRMT5 in various biological processes, including cancer progression and gene regulation.
PRMT5-IN-41 is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5), demonstrating potent enzymatic inhibition with oral bioavailability. In addition to its primary mechanism, PRMT5-IN-41 exhibits off-target inhibition of the hERG ion channel, with an IC50 value of 1.36 µM. This compound is valuable for research applications investigating the role of PRMT5 in various biological processes, including cancer progression and gene regulation.
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