CMP-5 hydrochloride is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5), demonstrating no activity against PRMT1, PRMT4, or PRMT7. This compound effectively blocks the methylation of histone H4 at arginine 3 (S2Me-H4R3) by inhibiting PRMT5 methyltransferase activity. CMP-5 hydrochloride has shown the ability to prevent transformation of EBV-driven B-lymphocytes while sparing normal B cells, making it a valuable tool for research in cancer biology and epigenetic modulation.
CMP-5 hydrochloride is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5), demonstrating no activity against PRMT1, PRMT4, or PRMT7. This compound effectively blocks the methylation of histone H4 at arginine 3 (S2Me-H4R3) by inhibiting PRMT5 methyltransferase activity. CMP-5 hydrochloride has shown the ability to prevent transformation of EBV-driven B-lymphocytes while sparing normal B cells, making it a valuable tool for research in cancer biology and epigenetic modulation.
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