Propargyl-C8-amido-PEG2-NHS ester is a non-cleavable linker designed for use in antibody-drug conjugates (ADCs) with a primary mechanism of enabling stable conjugation through click chemistry. This reagent contains an alkyne functional group, allowing for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. Its application spans the development of targeted therapies by facilitating the precise attachment of cytotoxic drugs to antibodies, enhancing therapeutic efficacy while minimizing off-target effects.
Propargyl-C8-amido-PEG2-NHS ester is a non-cleavable linker designed for use in antibody-drug conjugates (ADCs) with a primary mechanism of enabling stable conjugation through click chemistry. This reagent contains an alkyne functional group, allowing for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. Its application spans the development of targeted therapies by facilitating the precise attachment of cytotoxic drugs to antibodies, enhancing therapeutic efficacy while minimizing off-target effects.
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