Propargyl-PEG4-CH2-methyl ester

Catalog No.: A83638
PROTAC Linker
Propargyl-PEG4-CH2-methyl ester functions as a PEG-based linker for the synthesis of PROTACs (proteolysis-targeting chimeras). Its alkyne group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the assembly of complex molecular architectures. This compound is essential for researchers aiming to develop targeted protein degradation technologies in drug discovery and chemical biology.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPropargyl-PEG4-CH2-methyl ester functions as a PEG-based linker for the synthesis of PROTACs (proteolysis-targeting chimeras). Its alkyne group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the assembly of complex molecular architectures. This compound is essential for researchers aiming to develop targeted protein degradation technologies in drug discovery and chemical biology.
Product Information
Catalog NumA83638
FormulaC14H24O6
Molecular Weight288.34
CAS Number1872433-63-0
SMILESC#CCOCCOCCOCCOCCCC(OC)=O
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