Prostaglandin E1-d9 is a deuterium-labeled derivative of Prostaglandin E1, functioning as a potent ligand for prostanoid receptors. It exhibits high affinity with inhibitory constants of 1.1 nM, 2.1 nM, 10 nM, 33 nM, and 36 nM for mouse EP3, EP4, EP2, IP, and EP1 receptors, respectively. As a stable isotope, Prostaglandin E1-d9 is valuable in metabolic studies and pharmacokinetic research, facilitating the investigation of prostanoid signaling pathways and their physiological effects, including vasodilation.
Prostaglandin E1-d9 is a deuterium-labeled derivative of Prostaglandin E1, functioning as a potent ligand for prostanoid receptors. It exhibits high affinity with inhibitory constants of 1.1 nM, 2.1 nM, 10 nM, 33 nM, and 36 nM for mouse EP3, EP4, EP2, IP, and EP1 receptors, respectively. As a stable isotope, Prostaglandin E1-d9 is valuable in metabolic studies and pharmacokinetic research, facilitating the investigation of prostanoid signaling pathways and their physiological effects, including vasodilation.
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