PROTAC Bcl2 degrader-1

Catalog No.: A18355

degrader

PROTAC Bcl2 degrader-1

PROTAC Bcl2 degrader-1 Chemical Structure

CAS NO. 2378801-85-3

PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$650.00
50 mg
$2,100.00
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Biological Activity

PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 10.62 mL 53.09 mL 106.18 mL
0.5 mM 2.12 mL 10.62 mL 21.24 mL
1 mM 1.06 mL 5.31 mL 10.62 mL
5 mM 0.21 mL 1.06 mL 2.12 mL

*The above data is based on the productmolecular weight 941.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18355
Actions Degrader
CAS No. 2378801-85-3
Formula C45H45BrN6O10S
M. Wt 941.84
Solubility DMSO
Purity >98%
SMILES O=C(NCCOCCOCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)CCCCC(NCCN4C(C5=C6C(C4=O)=CC=C(C6=CC=C5)SC7=CC=C(C=C7)Br)=O)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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