PROTAC SMARCA2/4-degrader-31 is a targeted degradative agent designed to induce proteolytic degradation of the catalytic subunits SMARCA2 and SMARCA4 within the SWI/SNF chromatin remodeling complex. This compound demonstrates effective degradation of SMARCA2 in A549 cells with a DC50 of less than 100 nM and SMARCA4 in MV411 cells, also with a DC50 below 100 nM. It is a valuable tool for studying the functional roles of these proteins in cancer biology and epigenetic regulation.
PROTAC SMARCA2/4-degrader-31 is a targeted degradative agent designed to induce proteolytic degradation of the catalytic subunits SMARCA2 and SMARCA4 within the SWI/SNF chromatin remodeling complex. This compound demonstrates effective degradation of SMARCA2 in A549 cells with a DC50 of less than 100 nM and SMARCA4 in MV411 cells, also with a DC50 below 100 nM. It is a valuable tool for studying the functional roles of these proteins in cancer biology and epigenetic regulation.
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