PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a targeted PROTAC degrader that specifically promotes the degradation of the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It demonstrates robust biological activity, achieving degradation of SMARCA2 and SMARCA4 in MV411 and A549 cell lines with DC50 values below 100 nM. This compound is valuable for research applications focused on the modulation of chromatin remodeling processes and the elucidation of the roles of SMARCA proteins in cancer biology.
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a targeted PROTAC degrader that specifically promotes the degradation of the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It demonstrates robust biological activity, achieving degradation of SMARCA2 and SMARCA4 in MV411 and A549 cell lines with DC50 values below 100 nM. This compound is valuable for research applications focused on the modulation of chromatin remodeling processes and the elucidation of the roles of SMARCA proteins in cancer biology.
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