PROTAC SMARCA2/4-degrader-9 is a targeted protein degrader that specifically targets the catalytic subunits of the SWI/SNF complexes, SMARCA2 and SMARCA4. This compound effectively degrades SMARCA2 in MV411 and A549 cell lines with a DC50 value of less than 100 nM, while also demonstrating similar potency against SMARCA4 in MV411 cells. PROTAC SMARCA2/4-degrader-9 serves as a valuable tool for studying the biological functions of these proteins and their roles in cancer research and therapeutic development.
PROTAC SMARCA2/4-degrader-9 is a targeted protein degrader that specifically targets the catalytic subunits of the SWI/SNF complexes, SMARCA2 and SMARCA4. This compound effectively degrades SMARCA2 in MV411 and A549 cell lines with a DC50 value of less than 100 nM, while also demonstrating similar potency against SMARCA4 in MV411 cells. PROTAC SMARCA2/4-degrader-9 serves as a valuable tool for studying the biological functions of these proteins and their roles in cancer research and therapeutic development.
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