PROTAC SMARCA2 degrader-20

Catalog No.: A40454
PROTAC SMARCA2 Degrader
PROTAC SMARCA2 degrader-20 (Compound I-40) is an innovative PROTAC molecule designed to selectively target and degrade the SMARCA2 protein. This compound facilitates the ubiquitination and subsequent proteasomal degradation of SMARCA2, offering a unique approach to modulate its biological activity. It is primarily utilized in cancer research to explore novel therapeutic pathways and to investigate the role of SMARCA2 in tumorigenesis and other related mechanisms.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPROTAC SMARCA2 degrader-20 (Compound I-40) is an innovative PROTAC molecule designed to selectively target and degrade the SMARCA2 protein. This compound facilitates the ubiquitination and subsequent proteasomal degradation of SMARCA2, offering a unique approach to modulate its biological activity. It is primarily utilized in cancer research to explore novel therapeutic pathways and to investigate the role of SMARCA2 in tumorigenesis and other related mechanisms.
Product Information
Catalog NumA40454
FormulaC55H65N11O5S
Molecular Weight992.24
CAS Number2660324-41-2
SMILESCC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(C4CC5(CC(C5)N6CCC(CC6)C7=CN=C(N=C7)N8CCC9=C([C@H]8C)C%10=C(N9)N=NC(C%11=C(C=CC=C%11)O)=C%10)C4)=O)=O)O)=O
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