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PROTAC SMARCA2 degrader-3

Catalog No.: A40511
PROTAC SMARCA2 Degrader
PROTAC SMARCA2 degrader-3 is a PROTAC degrader specifically targeting the SWI/SNF ATPase subunit SMARCA2. This compound induces proteasomal degradation of SMARCA2, demonstrating significant anticancer activity. It is valuable for research applications focused on cancer biology and the exploration of therapeutic strategies targeting chromatin remodeling complexes.
PROTAC SMARCA2 degrader-3 3024266-69-8 PROTAC SMARCA2 Degrader
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPROTAC SMARCA2 degrader-3 is a PROTAC degrader specifically targeting the SWI/SNF ATPase subunit SMARCA2. This compound induces proteasomal degradation of SMARCA2, demonstrating significant anticancer activity. It is valuable for research applications focused on cancer biology and the exploration of therapeutic strategies targeting chromatin remodeling complexes.
Product Information
Catalog NumA40511
FormulaC37H42N8O4
Molecular Weight662.78
CAS Number3024266-69-8
SMILESNC1=C(C=C(C2=CC=CC=C2O)N=N1)C(C=N3)=CN3C(CC4)CCN4[C@@H](CC5)CC[C@@H]5C6=C(OCCN7C8C(NC(CC8)=O)=O)C7=CC=C6
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Epigenetics > Epigenetic Reader Domain
PROTAC > PROTAC Degrader