Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Neprilysin inhibitors block a zinc endopeptidase that inactivates natriuretic and opioid peptides. Neprilysin (NEP), also called neutral endopeptidase, was purified in 1974 from rabbit kidney brush border membranes. In 1978 a high-affinity enkephalin-degrading peptidase was described in brain, and the activity became known as enkephalinase. Further NEP substrates include atrial natriuretic peptide, bradykinin, substance P and amyloid-β peptides. Sacubitril calcium and candoxatril are prodrugs, and sacubitrilat is the active form of sacubitril. Racecadotril is a prodrug of an enkephalinase inhibitor, and phosphoramidon disodium salt is a microbial metalloendopeptidase inhibitor. Omapatrilat blocks both NEP and angiotensin-converting enzyme (ACE), while Sacubitril/Valsartan combines NEP inhibition with angiotensin receptor blockade.
