Fig. 1 · Structure
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Prucalopride hydrochloride
5-HT4 Agonist
Prucalopride hydrochloride is a selective and specific agonist for the 5-HT4 receptor, with high affinity identified by pKis of 8.6 and 8.1 for the human 5-HT4a and 4b subtypes, respectively. This compound enhances intestinal motility by facilitating the regeneration of the intestinal nervous system, as demonstrated in rodent models. Additionally, Prucalopride hydrochloride exhibits anticancer properties through the inhibition of the PI3K/AKT/mTOR signaling pathway. Its applications are relevant in research focused on chronic constipation, pseudo-intestinal obstruction, and cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 179474-80-7 |
| Applications | 5-HT4 Agonist |
| Formula | C18H27Cl2N3O3 |
| Molecular Weight | 404.33 |
| SMILES | ClC1=C(N)C(CCO2)=C2C(C(NC3CCN(CCCOC)CC3)=O)=C1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.