Fig. 1 · Structure
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Pruvanserin hydrochloride
5-HT2A Receptor Antagonist
Pruvanserin hydrochloride is a selective antagonist of the serotonin 5-HT2A receptor, exhibiting IC50 values of 0.35 nM and 1 nM for human and rat receptors, respectively. This compound is primarily utilized in scientific research focused on schizophrenia, aiding in the exploration of therapeutic strategies targeting serotonergic pathways. Its high selectivity and potency make it a valuable tool in the study of neuropsychiatric disorders associated with serotonin dysregulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 443144-27-2 |
| Applications | 5-HT2A Receptor Antagonist |
| Formula | C22H22ClFN4O |
| Molecular Weight | 412.89 |
| Synonyms | EMD 281014; LY 2422347 hydrochloride |
| SMILES | N#CC1=CNC2=C1C=CC=C2C(N3CCN(CC3)CCC4=CC=C(C=C4)F)=O.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.