Fig. 1 · Structure
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PSI-7409 tetrasodium
HCV NS5B Inhibitor
PSI-7409 tetrasodium is a potent HCV NS5B polymerase inhibitor, functioning as the active 5'-triphosphate metabolite of sofosbuvir (PSI-7977). It exhibits effective inhibition with IC50 values of 1.6 μM for GT 1b_Con1, 2.8 μM for GT 2a_JFH1, 0.7 μM for GT 3a, and 2.6 μM for GT 4a NS5B polymerases. This compound is essential for research applications related to hepatitis C virus replication and provides a valuable tool for the development of antiviral therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1621884-22-7 |
| Applications | HCV NS5B Inhibitor |
| Formula | C10H12FN2Na4O14P3 |
| Molecular Weight | 588.09 |
| SMILES | O[C@@H]([C@@](C)(F)[C@H](N1C(NC(C=C1)=O)=O)O2)[C@H]2COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.