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PTP1B-IN-33

PTP1B Inhibitor

PTP1B-IN-33 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with a human IC50 of 2.45 μM, exhibiting over 20-fold selectivity for PTP1B relative to SHP2. By enhancing π-Alkyl interactions, it promotes a higher degree of closure in the WPD loop, facilitating more effective inhibition of PTP1B activity. This compound is valuable for research into cancer, diabetes, and autoimmune deficiency diseases, providing insights into therapeutic strategies targeting PTP1B-mediated pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	77500-30-2
Applications	PTP1B Inhibitor
Formula	C₁₈H₁₄N₂O₃
Molecular Weight	306.32
SMILES	O=C(C1=CC=C(O1)C(NC2=CC=CC=C2)=O)NC3=CC=CC=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.