PU139 is a potent pan-histone acetyltransferase (HAT) inhibitor that specifically targets Gcn5, p300/CBP-associated factor (PCAF), CREB-binding protein (CBP), and p300. This compound demonstrates inhibitory activity with IC50 values of 8.39 μM, 9.74 μM, 2.49 μM, and 5.35 μM for each respective HAT. PU139 is valuable for research applications exploring histone acetylation and its roles in gene regulation, cellular signaling, and cancer biology.
PU139 is a potent pan-histone acetyltransferase (HAT) inhibitor that specifically targets Gcn5, p300/CBP-associated factor (PCAF), CREB-binding protein (CBP), and p300. This compound demonstrates inhibitory activity with IC50 values of 8.39 μM, 9.74 μM, 2.49 μM, and 5.35 μM for each respective HAT. PU139 is valuable for research applications exploring histone acetylation and its roles in gene regulation, cellular signaling, and cancer biology.
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