Fig. 1 · Structure
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PXS-4787 hydrochloride
LOX Inhibitor
PXS-4787 hydrochloride is a selective pan-lysyl oxidase (LOX) inhibitor, effectively disrupting lysyl oxidase activity. It demonstrates potent inhibition with IC50 values of 2 μM for Bovine LOX, 3.2 μM for recombinant human LOXL1, 0.6 μM for rh LOXL2, 1.4 μM for rh LOXL3, and 0.2 μM for rh LOXL4. PXS-4787 hydrochloride has been shown to reduce the deposition and crosslinking of collagen I in human fibroblasts, making it a valuable tool for studying fibrosis and connective tissue disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2409964-40-3 |
| Applications | LOX Inhibitor |
| Formula | C10H13ClFNO2S |
| Molecular Weight | 265.73 |
| SMILES | NC/C=C(CS(=O)(C1=CC=CC=C1)=O)\F.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.