Fig. 1 · Structure

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PXS-6302

LOX Inhibitor

PXS-6302 is an irreversible inhibitor of lysyl oxidase (LOX) with a competitive profile against various isoforms, showing IC50 values of 3.7 μM for bovine LOX, 3.4 μM for recombinant human LOXL1, 0.4 μM for recombinant human LOXL2, 1.5 μM for recombinant human LOXL3, and 0.3 μM for recombinant human LOXL4. This compound demonstrates significant biological activity by reducing collagen deposition and enhancing the aesthetic appearance of scars. PXS-6302 is particularly valuable in research applications focusing on fibrosis, wound healing, and skin remodeling.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 2584947-54-4
Applications LOX Inhibitor
Formula C10H10F3NO2S
Molecular Weight 265.25
SMILES
NC/C=C(C(F)(S(=O)(C1=CC=CC=C1)=O)F)\F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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