PZ-1129 is a selective ligand for the 5-HT7 receptor, exhibiting a Ki of 7 nM, with moderate affinity for 5-HT1A and D2 receptors (Ki values of 159 nM and 24 nM, respectively). This compound effectively inhibits constitutive cAMP production via the Gs signaling pathway, with an EC50 of 13.7 nM. PZ-1129 is suitable for research into emotional disorders, including depression and bipolar disorder, providing a valuable tool for understanding the underlying mechanisms of these conditions.
PZ-1129 is a selective ligand for the 5-HT7 receptor, exhibiting a Ki of 7 nM, with moderate affinity for 5-HT1A and D2 receptors (Ki values of 159 nM and 24 nM, respectively). This compound effectively inhibits constitutive cAMP production via the Gs signaling pathway, with an EC50 of 13.7 nM. PZ-1129 is suitable for research into emotional disorders, including depression and bipolar disorder, providing a valuable tool for understanding the underlying mechanisms of these conditions.
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