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Form	MW
QBS10072S This page	333.25
QBS10072S dihydrochloride	406.18

QBS10072S

Antitumor Agent

QBS10072S is a bifunctional chemotherapeutic agent that targets LAT1, facilitating drug delivery across the blood-brain barrier. This compound demonstrates potent inhibition of LAT1-mediated substrate uptake, with an IC50 of 21 μM, significantly outperforming its effect on LAT2 (IC50 = 1100 μM). QBS10072S enters LAT1-expressing tumor cells via active transport, leading to DNA interstrand crosslinking, subsequent DNA damage, and cell death. It is valuable for research applications focused on glioblastoma and aggressive T-cell lymphoma.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Substrate
CAS Number	1802735-28-9
Applications	Antitumor Agent
Formula	C₁₅H₂₂Cl₂N₂O₂
Molecular Weight	333.25
SMILES	CC1=C(C[C@@H](CC(O)=O)N)C=C(N(CCCl)CCCl)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.