Fig. 1 · Structure
Documents & Downloads
R 59-022 hydrochloride
DGK Inhibitor
R 59-022 hydrochloride is a potent diacylglycerol kinase (DGK) inhibitor, exhibiting an IC50 of 2.8 µM. This compound inhibits the conversion of 1-oleoyl-2-acetylglycerol (OAG) to O-phosphoacylglycerol (OAPA) while also acting as a 5-HT receptor antagonist. Additionally, R 59-022 hydrochloride activates protein kinase C (PKC), enhances thrombin-induced diacylglycerol production in platelets, and suppresses phosphatidic acid synthesis in neutrophils. Its applications include investigations into platelet activation and neutrophil signaling pathways.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 93076-98-3 |
| Applications | DGK Inhibitor |
| Formula | C27H27ClFN3OS |
| Molecular Weight | 496.04 |
| Synonyms | DKGI-I hydrochloride; Diacylglycerol kinase inhibitor I hydrochloride |
| SMILES | O=C1C(CCN(CC/2)CCC2=C(C3=CC=CC=C3)/C4=CC=C(F)C=C4)=C(C)N=C5N1C=CS5.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.