Fig. 1 · Structure
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(R)-Azasetron besylate
Calcineurin Inhibitor
(R)-Azasetron besylate is an orally active calcineurin inhibitor that modulates calcineurin activity, thereby influencing T-cell signaling pathways. It has demonstrated effectiveness in reducing Cisplatin-induced hearing loss and cochlear damage, making it a valuable reagent for research into ototoxicity and protective strategies against auditory toxicity. This compound is of particular interest in studies focusing on hearing preservation and interventions in cancer treatment-related hearing loss.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2025360-91-0 |
| Applications | Calcineurin Inhibitor |
| Formula | C23H26ClN3O6S |
| Molecular Weight | 507.99 |
| Synonyms | SENS-401 |
| SMILES | O=S(O)(C1=CC=CC=C1)=O.O=C(C2=C(OCC(N3C)=O)C3=CC(Cl)=C2)N[C@H]4CN5CCC4CC5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.