Fig. 1 · Structure
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(R)-cGAS-IN-4
R-enantiomer of cGAS-IN-4
(R)-cGAS-IN-4 is the R-enantiomer of cGAS-IN-4, functioning as an orally active inhibitor of cyclic GMP-AMP synthase (cGAS). This compound effectively modulates the cGAS pathway, which is crucial in the innate immune response to cytosolic DNA. Its inhibitory action makes it a valuable tool for research applications focused on understanding cGAS-related signaling pathways and their roles in inflammatory diseases and cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2987886-48-4 |
| Applications | R-enantiomer of cGAS-IN-4 |
| Formula | C19H18Cl2N4O3 |
| Molecular Weight | 421.28 |
| SMILES | C[C@@H]1C(C2=CC=C3Cl)=C(CCN1C(C4=NC=C(OCCO)C=N4)=O)NC2=C3Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.