Fig. 1 · Structure
Documents & Downloads
(R)-MK-5046
Isomer
(R)-MK-5046 is the isomer of MK-5046 and serves as a valuable experimental control in research. This compound acts as a potent and selective allosteric agonist of the Bombesin receptor subtype-3 (BRS-3), exhibiting an IC50 value of 27 nM and an EC50 of 25 nM for human BRS-3. (R)-MK-5046 has been shown to inhibit food intake and reduce body weight in diet-induced obese mouse models, making it a useful tool for investigating mechanisms underlying obesity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1021736-25-3 |
| Applications | Isomer |
| Formula | C20H18F6N4O |
| Molecular Weight | 444.37 |
| SMILES | O[C@@](CC1=NC(CC2(C(F)(F)F)CC2)=CN1)(C(F)(F)F)C3=CC=C(N4C=CC=N4)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.