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(R)-Nolpitantium

NK1 Receptor Antagonist

(R)-Nolpitantium is a potent and selective antagonist targeting the NK1 receptor. By competitively inhibiting tachykinin activity, (R)-Nolpitantium effectively blocks neuronal activation in the rat thalamus following nociceptive stimulation. This compound is valuable for research applications studying pain pathways and the role of tachykinin signaling in neurobiology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	154728-59-3
Applications	NK1 Receptor Antagonist
Formula	C₃₇H₄₅Cl₃N₂O₂
Molecular Weight	656.12
Synonyms	SR140603
SMILES	O=C(N1C[C@](CC[N+]2(CC3)CCC3(C4=CC=CC=C4)CC2)(C5=CC=C(Cl)C(Cl)=C5)CCC1)CC6=CC=CC(OC(C)C)=C6.[Cl-]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.