Fig. 1 · Structure
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(R)-Plevitrexed
Plevitrexed Enantiomer
(R)-Plevitrexed is a enantiomer of Plevitrexed, targeting thymidylate synthase (TS) as a potent inhibitor. While exhibiting reduced biological activity compared to its counterpart, (R)-Plevitrexed serves as a valuable click chemistry reagent due to its alkyne group. It is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating efficient labeling and conjugation in various biological research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 153537-74-7 |
| Applications | Plevitrexed Enantiomer |
| Formula | C26H25FN8O4 |
| Molecular Weight | 532.53 |
| Synonyms | (R)-ZD 9331; (R)-BGC9331 |
| SMILES | O=C(NC(C)=N1)C2=C1C=C(C)C(CN(C3=CC=C(C(N[C@@H](C(O)=O)CCC4=NNN=N4)=O)C(F)=C3)CC#C)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.