Fig. 1 · Structure
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Plevitrexed
Thymidylate Synthase Inhibitor
Plevitrexed is a potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM, primarily utilized in the treatment of gastric cancer. It is absorbed through the α-folate receptor and the reduced folate carrier, demonstrating its effectiveness in targeting cancer cells. Additionally, Plevitrexed features an alkyne group, making it suitable for click chemistry applications, specifically in copper-catalyzed azide-alkyne cycloaddition (CuAAc), allowing for the functionalization of azide-containing molecules in biological research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 153537-73-6 |
| Applications | Thymidylate Synthase Inhibitor |
| Formula | C26H25FN8O4 |
| Molecular Weight | 532.53 |
| Synonyms | ZD 9331; BGC9331 |
| SMILES | O=C(NC(C)=N1)C2=C1C=C(C)C(CN(C3=CC=C(C(N[C@H](C(O)=O)CCC4=NNN=N4)=O)C(F)=C3)CC#C)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.