Fig. 1 · Structure
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(R)-Pralatrexate
(R)-Enantiomer
(R)-Pralatrexate is the (R)-enantiomer of Pralatrexate, functioning primarily as a potent inhibitor of dihydrofolate reductase (DHFR). As an antifolate compound, it demonstrates significant biological activity by disrupting folate metabolism, which is essential for DNA synthesis. This makes (R)-Pralatrexate valuable in cancer research and potential therapeutic applications targeting malignant cells with high proliferation rates. Researchers may utilize this compound in studies aimed at understanding the mechanisms of antifolate resistance and the development of targeted cancer therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1320211-70-8 |
| Applications | (R)-Enantiomer |
| Formula | C23H23N7O5 |
| Molecular Weight | 477.47 |
| SMILES | O=C(CC[C@H](NC(C1=CC=C(C=C1)[C@H](CC#C)CC2=NC3=C(N=C(N=C3N=C2)N)N)=O)C(O)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.