Fig. 1 · Structure
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(R)-RO5263397
Trace Amine-associated Receptor (TAAR) Agonist
(R)-RO5263397 is a selective agonist of the Trace Amine-associated Receptor 1 (TAAR1). This compound has shown significant biological activity in reducing cocaine-related behaviors, including diminishing cocaine-induced behavioral sensitization, attenuating cue-induced reinstatement of cocaine-seeking behavior, and modulating conditioned place preference for cocaine. Its utility in research highlights the potential of targeting TAAR1 in the context of addiction and substance use disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1357266-80-8 |
| Applications | Trace Amine-associated Receptor (TAAR) Agonist |
| Formula | C10H11FN2O |
| Molecular Weight | 194.21 |
| SMILES | CC1=C(C=CC=C1[C@@H]2COC(N)=N2)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.