Fig. 1 · Structure
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RO5263397
TAAR1 Agonist
RO5263397 is a potent and selective agonist of the trace amine-associated receptor 1 (TAAR1), exhibiting EC50 values of 17 nM for human TAAR1 and 35 nM for rat TAAR1. This compound effectively modulates wakefulness and influences EEG spectral composition, demonstrating potential antidepressant-like properties. It serves as a valuable tool for investigating the role of TAAR1 in neuropsychiatric disorders and understanding its physiological functions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1357266-05-7 |
| Applications | TAAR1 Agonist |
| Formula | C10H11FN2O |
| Molecular Weight | 194.21 |
| SMILES | CC1=C([C@@H]2N=C(N)OC2)C=CC=C1F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.