Fig. 1 · Structure
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R419
Complex I Inhibitor
R419 is a potent inhibitor of Complex I, the first enzyme in the mitochondrial electron transport chain. It demonstrates significant anti-cancer activity, particularly against liver cancer, by inducing apoptosis and impairing mitochondrial function. This compound is valuable for research focused on mitochondrial metabolism in cancer cells and exploring potential therapeutic strategies for hepatic malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1356629-00-9 |
| Applications | Complex I Inhibitor |
| Formula | C33H35N5O4 |
| Molecular Weight | 565.66 |
| SMILES | N#CC1=CC=C(CN2CCC(CC2)NC(C3=CN=C(C(N4CCC(CC4)C(C5=CC=C(C=C5)OC)=O)=O)C=C3)=O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.