(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I, exhibiting a binding affinity of Ki=19 nM. This compound displays reduced binding to calpain II (Ki=120 nM) and cathepsin B (Ki=750 nM), making it a valuable tool for dissecting calpain-related biochemical pathways. Its applications span various fields, including studies on neutrophil chemotaxis, neuronal signaling, and cardiac responses to injury, facilitating insights into calpain's role in cellular processes and pathologies.
(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I, exhibiting a binding affinity of Ki=19 nM. This compound displays reduced binding to calpain II (Ki=120 nM) and cathepsin B (Ki=750 nM), making it a valuable tool for dissecting calpain-related biochemical pathways. Its applications span various fields, including studies on neutrophil chemotaxis, neuronal signaling, and cardiac responses to injury, facilitating insights into calpain's role in cellular processes and pathologies.
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