Fig. 1 · Structure
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(Rac)-GSK-3484862
Isomer
(Rac)-GSK-3484862 serves as an experimental control isomer of GSK-3484862, a potent non-covalent inhibitor of DNA methyltransferase 1 (Dnmt1). This compound is notably involved in inducing DNA hypomethylation, presenting a strategic approach in cancer research. Additionally, (Rac)-GSK-3484862 demonstrates significant demethylation effects in murine embryonic stem cells while minimizing non-specific toxicity, making it valuable for studies of epigenetic regulation and cancer therapeutics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2170136-02-2 |
| Applications | Isomer |
| Formula | C19H19N5OS |
| Molecular Weight | 365.45 |
| SMILES | O=C(N)C(SC1=NC(N(C)C)=C(C#N)C(CC)=C1C#N)C2=CC=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.