Fig. 1 · Structure
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(Rac)-Tanomastat
MMPs Inhibitor
(Rac)-Tanomastat is a racemic mixture of the non-peptidic biphenyl compound Tanomastat, which functions as a selective inhibitor of matrix metalloproteinases (MMPs) through a zinc-binding carboxyl group. It exhibits Ki values of 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, and MMP-13, respectively. This compound demonstrates significant anti-invasive and antimetastatic properties in various experimental tumor models, making it a valuable tool for cancer research and therapeutic investigations focused on metastasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 179545-76-7 |
| Applications | MMPs Inhibitor |
| Formula | C23H19ClO3S |
| Molecular Weight | 410.91 |
| Synonyms | (Rac)-BAY 12-9566 |
| SMILES | ClC1=CC=C(C=C1)C2=CC=C(C=C2)C(CC(CSC3=CC=CC=C3)C(O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.